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The Infinity Run Flyknit 2 features an updated upper, offering increased breathability and support, along with a more cushioned tongue and ankle collar for improved comfort. Nike created the original Infinity Run Flyknit with the ambition of reducing the likelihood of injury through the use of soft yet springy React foam and the geometry of the midsole. Nike also worked with the British Columbia Sports Medicine Research Foundation to understand the effectiveness of the midsole design. The same midsole has been used in the Infinity Run Flyknit 2.